VOLUMINOUS 10 YEARS APART CONTRALATERAL RECURRENCE OF A MATURE TERATOMA – A CASE REPORT
Keywords:
dermoid cyst, recurrence, contralateral mature teratoma
Abstract
Original in germ line cells, ovarian teratoma is frequent in childhood, young and adult women before the age of 40. Mature teratoma, also known as a dermoid cyst, is among the most common ovarian masses, with an incidence of up to 58% of benign ovarian tumors. Frequently diagnosed during the routine gynecological examination, the symptomatology of those ovarian tumors is mild and nonspecific. Proper evaluation of a suspected teratoma should be performed to establish the benign or malignant characteristics of the tumor. Though with a low risk of recurrence, especially within the first year after the first encounter, the reccurrence rate is up to 21% and can occur even after 15 years. Surgical treatment is the gold standard in the management of this medical condition. Patients should be routinely evaluated for recurrences and possible complications.
We present a case of a 35 years old woman with 10 years apart contralateral recurrence of a dermoid cyst. Before the second encounter, the patient had regular examinations with no abnormal findings. This case is particular because of the prolonged timeframe to the second diagnosis. The initial characteristics of the dermoid cyst were considered to be at high risk for early recurrence within the first year following the first surgical excision.
References
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[23] M. Hamza, T. Yasmeen, IA. Nadeem, N. Fatima, S. Fatima, M.Huzaifa „Ovarian dermoid cyst presenting with unusual complaint of hair coming out of the anal orifice - A case report.” J Pak Med Assoc. Mar;70(3):534-536, 2020.
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[25] M. Pekar-Zlotin, I. Rabinovich, I. Goldrat, Z .Vaknin, Y. Gidoni, H. Zur-Naaman, R. Maymon, N. Smorgick „Ovarian Dermoid Cysts Associated with Paraneoplastic Syndrome N-methyl-D-aspartic Acid Receptor Antibodies Encephalitis.” J Minim Invasive Gynecol. Jun;28(6):1190-1193, 2021.
[26] A. Emamian, D. Santi, M. Appu, W. Tcheng, KS. Fernandez. „Ovarian teratoma masquerading as encephalitis in an adolescent. Pediatr Blood Cancer. Jul;68(7): e29027, 2021.
[27] MA. „An unusual presentation of ovarian dermoid cyst: a case report and review of literature.” Obstet Gynecol Sci. Jul;61(4):529-532, 2018.
[28] S, Salehpour, A.Akbari Sene „Super infection of an ovarian dermoid cyst with actinomyces in an infertile woman.” Int J Fertil Steril. Jul;7(2):134-7, 2013
[29] L. Qin, X .Zhao,. H. Liu,., X. Wang,. D. Gu., Z . Chen, , D. Wang. He. „Malignant transformation arising from mature ovarian cystic teratoma: A case series.” Medicine (Baltimore). Apr 2;100(13): e24726, 2021.
[30] A. Tehranian, A. Ghahghaei-Nezamabadi, A. Seifollahi, S. Kasraei, H. Dehghani-Nejad, A. Maleki-Hajiagha „Ovarian mature cystic teratoma with malignant transformation: two case reports.” J Med Case Rep. Jan 27;15(1):23, 2021.
[31] N.Toba, T. Takahashi, K. Ota, A. Takanashi, Y. Iizawa, Y. Endo, S. Furukawa, S.Soeda,T . Watanabe, H. Mizunuma, K. Fujimori,K.Takeichi „Malignant transformation arising from mature cystic teratoma of the ovary presenting as ovarian torsion: a case report and literature review”. Fukushima J Med Sci. Apr 22;66(1):44-52, 2020.
[32] H. Ganer Herman, R. Sagiv, H. Raphaeli, R. Kerner, R. Keidar, J. Bar Ginath S. „Surgical treatment of mature cystic teratomas: A comparison of emergent and elective surgeries”. J Obstet Gynaecol Res. Jan;43(1):190-195, 2017.
[33] J. Li, X. Wu „Current Strategy for the Treatment of Ovarian Germ Cell Tumors: Role of Extensive Surgery.” Curr Treat Options Oncol. Aug;17(8):44, 2016.
[34] D. Kiely, C. Lewis, J. Gray, N. Hall „Prevalence of metachronous contralateral mature ovarian teratoma: A systematic review.” Pediatr Blood Cancer. Nov;68(11): e29237, 2021.
[35] N. Eisenberg, A. Volodarsky-Perel, I. Brochu, C. Tremblay, E. Gorak, E. Hudon, S. Fortin, L. Kogan, C. Rivard „Short- and Long-Term Complications of Intraoperative Benign Ovarian Cyst Spillage: A Systematic Review and Meta-analysis.” J Minim Invasive Gynecol. May;28(5):957-970, 2021.
[36] C. Karadağ, S. Demircan, A. Turgut, E. Çalışkan „Effects of laparoscopic cystectomy on ovarian reserve in patients with endometrioma and dermoid cyst”. Turk J Obstet Gynecol. Mar;17(1):15-20, 2020.
[37] A. Takeda, S. Imoto, H. Nakamura „Management of pediatric and adolescent adnexal masses by gasless laparoendoscopic single-site surgery.” Eur J Obstet Gynecol Reprod Biol. Oct; 181:66-71, 2014.
[38] C. Hernandez-Nieto, JA. Lee, K. Gonzalez, T. Mukherjee, AB. Copperman, Sandler B. „Conservative treatment versus surgical excision of ovarian dermoid cysts: Impact on ovarian stimulation and IVF cycle success.” Int J Gynaecol Obstet. Mar;148(3):392-398, 2020.
[2] R. Ramamurthi, P. Rajaguru. „Bilateral Recurrent Ovarian Cysts: A Case Report”. International Journal of Current Medical and Applied Sciences, vol.5. Issue 2, January: PP: 104-106, 2015.
[3] A. Moridi, M. Arab, G. Fazli, M. Khayamzadeh. “Clinical Points in Dermoid Cyst Management: A Review Article”. Obstet Gynecol Cancer Res. November; 1(3): e10034, 2016.
[4] JT. Veneris, P. Mahajan, AL. Frazier. „Contemporary management of ovarian germ cell tumors and remaining controversies”. Gynecol Oncol. Aug;158(2):467-475, 2020
[5] I. Fayez, B. Khreisat, T. Athamneh, R. Omoosh, MA. Daibes. „Multiple Bilateral Ovarian Mature Cystic Teratomas with Ovarian Torsion: A Case Report.” Oman Med J. Mar;33(2):163-166, 2018.
[6] N. Kato, K. Sakamoto, K. Murakami, Y. Iwasaki, A. Kamataki, A. Kurose „Genetic zygosity of mature ovarian teratomas, struma ovarii, and ovarian carcinoids”. Virchows Arch. Aug;473(2):177-182, 2018.
[7] OL. Snir, M. DeJoseph, S. Wong, N. Buza, P. Hui „Frequent homozygosity in both mature and immature ovarian teratomas: a shared genetic basis of tumorigenesis.” Mod Pathol. Oct;30(10):1467-1475, 2017.
[8] K. Cagino, D.Levitan, N. Schatz-Siemers, R Zarnegar, E Chapman-Davis, K. Holcomb, M.Frey „Multiple malignant transformations of an ovarian mature cystic teratoma” Ecancermedicalscience. Feb 4; 14:1009, 2020.
[9] T. Saida, K. Mori, T. Masumoto, S. Hoshiai, T Ishiguro, Sakai M, Hara T, Ochi H, T. Satoh, M. Minami „Ovarian and non-ovarian teratomas: a wide spectrum of features.” Jpn J Radiol. Feb;39(2):143-158, 2021.
[10] J. Łuczak, M.Bagłaj, P. Dryjański. What recent primary studies tell us about ovarian teratomas in children: a scoping review. Cancer Metastasis Rev. Mar;39(1):321-329, 2020.
[11] WC. Wang, YC. Lai. „Evidence of metachronous development of ovarian teratomas: a case report of bilateral mature cystic teratomas of the ovaries and systematic literature review.” J Ovarian Res.;10(1):17. Published 2017 Mar 14. doi:10.1186/s13048-017-0313-8, 2017.
[12] M. Saleh, P. Bhosale, CO Menias, P Ramalingam, C Jensen, R Iyer, D. Ganeshan „Ovarian teratomas: clinical features, imaging findings and management.” Abdom Radiol (NY). Jun;46(6):2293-2307, 2021.
[13] S. Srisajjakul, P. Prapaisilp, S.Bangchokdee „Imaging features of unusual lesions and complications associated with ovarian mature cystic teratoma.” Clin Imaging. Sep-Oct; 57:115-123, 2019.
[14] F. Pepe, S. Lo Monaco, F. Rapisarda, G. Raciti, C.Genovese, P.Pepe „An unusual case of multiple and bilateral ovarian dermoid cysts” Case report. G Chir. Mar-Apr;35(3-4):75-7, 2014.
[15] YL. Lee, CR. Lai, MS. Yen. „Recurrent ovarian mixed germ cell tumor with unusual malignant transformation: a case report”. J Ovarian Res. Jan 10;12(1):2, 2019
[16] MR. Drylewicz, MG. Lubner, PJ. Pickhardt, CO.Menias, VM. Mellnick. „Fatty masses of the abdomen and pelvis and their complications”. Abdom Radiol (NY). Apr;44(4):1535-1553, 2019.
[17] I. Rabinovich, M. Pekar-Zlotin, Y. Bliman-Tal, Y. Melcer, Z. Vaknin, N. Smorgick „Dermoid cysts causing adnexal torsion: What are the risk factors?” Eur J Obstet Gynecol Reprod Biol. Aug; 251:20-22, 2020.
[18] S.Baradwan , W. Sendy , S. Sendy.”Bilateral dermoid ovarian torsion in a young woman: a case report”. J Med Case Rep. Jun 8;12(1):159, 2018.
[19] AD. Chang, K. Carter „Twisted Teeth: Ovarian Torsion Secondary to Mature Teratoma.” Cureus. Jan 14;12(1): e6649, 2020.
[20] HE. Kim, M. Seo, JY. Kwack, YS. Kwon „Granulomatous peritonitis caused by iatrogenic spillage of ovarian dermoid cystectomy: a case report and literature review.” Obstet Gynecol Sci. Jul;63(4):543-547, 2020.
[21] M. El Moussaoui,F. Closon, G. Brichant, N. Kotzampassakis, M.Nisolle „Chemical peritonitis complicating the spontaneous rupture of a dermoid cyst of the ovary.” Rev Med Liege. Jul;73(7-8):413-418, 2018.
[22] D. Bužinskienė, M. Mongirdas, S. Mikėnas, G. Drąsutienė, L. Andreika, I. Sakalauskaitė „Chemical peritonitis resulting from spontaneous rupture of a mature ovarian cystic teratoma: a case report.” Acta Med Litu.;26(4):217-226, 2019.
[23] M. Hamza, T. Yasmeen, IA. Nadeem, N. Fatima, S. Fatima, M.Huzaifa „Ovarian dermoid cyst presenting with unusual complaint of hair coming out of the anal orifice - A case report.” J Pak Med Assoc. Mar;70(3):534-536, 2020.
[24] HC. Chiu, YC. Su, SC. Huang, HL. Chiang, PS. Huang. „Anti-NMDAR encephalitis with ovarian teratomas: Review of the literature and two case reports.” Taiwan J Obstet Gynecol. May;58(3):313-317, 2019.
[25] M. Pekar-Zlotin, I. Rabinovich, I. Goldrat, Z .Vaknin, Y. Gidoni, H. Zur-Naaman, R. Maymon, N. Smorgick „Ovarian Dermoid Cysts Associated with Paraneoplastic Syndrome N-methyl-D-aspartic Acid Receptor Antibodies Encephalitis.” J Minim Invasive Gynecol. Jun;28(6):1190-1193, 2021.
[26] A. Emamian, D. Santi, M. Appu, W. Tcheng, KS. Fernandez. „Ovarian teratoma masquerading as encephalitis in an adolescent. Pediatr Blood Cancer. Jul;68(7): e29027, 2021.
[27] MA. „An unusual presentation of ovarian dermoid cyst: a case report and review of literature.” Obstet Gynecol Sci. Jul;61(4):529-532, 2018.
[28] S, Salehpour, A.Akbari Sene „Super infection of an ovarian dermoid cyst with actinomyces in an infertile woman.” Int J Fertil Steril. Jul;7(2):134-7, 2013
[29] L. Qin, X .Zhao,. H. Liu,., X. Wang,. D. Gu., Z . Chen, , D. Wang. He. „Malignant transformation arising from mature ovarian cystic teratoma: A case series.” Medicine (Baltimore). Apr 2;100(13): e24726, 2021.
[30] A. Tehranian, A. Ghahghaei-Nezamabadi, A. Seifollahi, S. Kasraei, H. Dehghani-Nejad, A. Maleki-Hajiagha „Ovarian mature cystic teratoma with malignant transformation: two case reports.” J Med Case Rep. Jan 27;15(1):23, 2021.
[31] N.Toba, T. Takahashi, K. Ota, A. Takanashi, Y. Iizawa, Y. Endo, S. Furukawa, S.Soeda,T . Watanabe, H. Mizunuma, K. Fujimori,K.Takeichi „Malignant transformation arising from mature cystic teratoma of the ovary presenting as ovarian torsion: a case report and literature review”. Fukushima J Med Sci. Apr 22;66(1):44-52, 2020.
[32] H. Ganer Herman, R. Sagiv, H. Raphaeli, R. Kerner, R. Keidar, J. Bar Ginath S. „Surgical treatment of mature cystic teratomas: A comparison of emergent and elective surgeries”. J Obstet Gynaecol Res. Jan;43(1):190-195, 2017.
[33] J. Li, X. Wu „Current Strategy for the Treatment of Ovarian Germ Cell Tumors: Role of Extensive Surgery.” Curr Treat Options Oncol. Aug;17(8):44, 2016.
[34] D. Kiely, C. Lewis, J. Gray, N. Hall „Prevalence of metachronous contralateral mature ovarian teratoma: A systematic review.” Pediatr Blood Cancer. Nov;68(11): e29237, 2021.
[35] N. Eisenberg, A. Volodarsky-Perel, I. Brochu, C. Tremblay, E. Gorak, E. Hudon, S. Fortin, L. Kogan, C. Rivard „Short- and Long-Term Complications of Intraoperative Benign Ovarian Cyst Spillage: A Systematic Review and Meta-analysis.” J Minim Invasive Gynecol. May;28(5):957-970, 2021.
[36] C. Karadağ, S. Demircan, A. Turgut, E. Çalışkan „Effects of laparoscopic cystectomy on ovarian reserve in patients with endometrioma and dermoid cyst”. Turk J Obstet Gynecol. Mar;17(1):15-20, 2020.
[37] A. Takeda, S. Imoto, H. Nakamura „Management of pediatric and adolescent adnexal masses by gasless laparoendoscopic single-site surgery.” Eur J Obstet Gynecol Reprod Biol. Oct; 181:66-71, 2014.
[38] C. Hernandez-Nieto, JA. Lee, K. Gonzalez, T. Mukherjee, AB. Copperman, Sandler B. „Conservative treatment versus surgical excision of ovarian dermoid cysts: Impact on ovarian stimulation and IVF cycle success.” Int J Gynaecol Obstet. Mar;148(3):392-398, 2020.
Published
2021-12-25
How to Cite
[1]
C. Mehedințu, “VOLUMINOUS 10 YEARS APART CONTRALATERAL RECURRENCE OF A MATURE TERATOMA – A CASE REPORT”, JSS, vol. 8, no. 3, Dec. 2021.
Section
Articles
