• Francesca Frîncu “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
  • Antoine Edu “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
  • Dumitru Cristinel Badiu
  • Mihai Cristian Dumitrașcu
  • Aida Petca
  • Andreea Carp-Velișcu
  • Claudia Mehedințu Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania &“Nicolae Malaxa” Clinical Hospital, Bucharest, Romania
Keywords: leiomyoma, infertility, minimally invasive, hysteroscopy, laparoscopy


Uterine fibroids are among the most common benign tumors in women of reproductive age. Their incidence is higher for African American women compared to Caucasian women. Women with fibroids may present with heterogeneous symptoms or may be diagnosed incidentally at routine checkups. Nowadays, a whole arsenal of diagnostic tools exists. Transvaginal ultrasound with color Doppler and 3D reconstruction, as well as hysteroscopy and nuclear magnetic resonance imaging (MRI), are the most useful. For the correct management of uterine fibroids, it is important to establish their location and type, according to existing classifications. Multiple studies have demonstrated their impact on fertility, especially in the case of submucosal, intracavitary ones. Most of the results in the literature on this issue come from assisted human reproduction clinics. This review aims to document the mechanisms by which uterine fibroids lead to low conception rates and clinical pregnancy rates and the available methods for their treatment to achieve pregnancy.



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