GASTRIC CARCINOMA BETWEEN HIGH GRADE NEUROENDOCRINE FEATURES AND ADENOCARCINOMA: A CASE REPORT AND BRIEF REVIEW OF LITERATURE

  • Denisa-Maria Zolofinoiu The University of Medicine and Pharmacy “Carol Davila”, Bucharest, Romania
  • O. Andronic The University of Medicine and Pharmacy “Carol Davila”, Bucharest, Romania
  • D.N. Păduraru The University of Medicine and Pharmacy “Carol Davila”, Bucharest, Romania & 3rd Department of General Surgery, University Emergency Hospital Bucharest, Romania
  • Alexandra Bolocan The University of Medicine and Pharmacy “Carol Davila”, Bucharest, Romania & 3rd Department of General Surgery, University Emergency Hospital Bucharest, Romania
  • T.A. Georgescu The University of Medicine and Pharmacy “Carol Davila”, Bucharest, Romania & Department of Pathology, The University Emergency Clinical Hospital, Bucharest, Romania
Keywords: MANEC, gastrectomy, immunostaining

Abstract

Mixed adenoneuroendocrine carcinoma (MANEC) is an exceptionally rare type of cancer associated to the gastrointestinal tract, without a clearly established and optimal therapeutic management. These tumors present with non-specific symptoms or histopathological findings to distinguish them from pure adenocarcinomas. We report the case of a 64-year-old male diagnosed with a high grade mixed adeneuroendocrine carcinoma of the gastric antrum, stage T2N3Mx. The patient underwent radical gastrectomy and the histopathological examination of the surgically resected specimen revealed a tumor mass containing both adenocarcinoma and poorly differentiated neuroendocrine components. Immunostaining for Chromogranin A and Synaptophysin was positive in the neuroendocrine component and negative in the adenocarcinoma component, which was positive for CK7 and CK20. Ki67 proliferation index was 95%. Using this report as reference, we also discuss the imunohistopathological features, clinical behavior and therapeutic management of mixed adenoneuroendocrine carcinomas, presenting a brief review of literature regarding this rare, yet highly aggressive tumor.

Published
2017-09-16
How to Cite
[1]
D.-M. Zolofinoiu, O. Andronic, D. Păduraru, A. Bolocan, and T. Georgescu, “GASTRIC CARCINOMA BETWEEN HIGH GRADE NEUROENDOCRINE FEATURES AND ADENOCARCINOMA: A CASE REPORT AND BRIEF REVIEW OF LITERATURE”, JSS, vol. 4, no. 3, pp. 121-126, Sep. 2017.
Section
Articles