• Iulian Slavu Bucharest Emergency Clinical Hospital, Bucharest, Romania
  • Adrian Tulin “Prof. Dr. Agrippa Ionescu” Emergency Clinical Hospital, Bucharest, Romania
  • Bogdan Socea “Saint Pantelimon” Emergency Clinical Hospital, Bucharest, Romania
  • Dan Nicolae Păduraru Bucharest Emergency University Hospital, Bucharest, Romania
  • Vlad Braga Bucharest Emergency Clinical Hospital, Bucharest, Romania
  • Lucian Alecu “Prof. Dr. Agrippa Ionescu” Emergency Clinical Hospital, Bucharest, Romania
Keywords: HIPEC, colorectal cancer, carcinomatosis


Cytoreductive surgery and HIPEC have become de pillars of treatment in advanced, metastatic colorectal cancer. This state of evolution of the disease was considered terminal just a few years ago.  It has been demonstrated that by combining these therapies in selected patients one can increase survival time. Once this has been obtained to some length modern studies have been focused on the quality of life, safety, and how this time interval can be increased. We have reviewed the most important prospective, randomized clinical trials regarding HIPEC and peritoneal carcinomatosis. The technique, complications, principles of action, and evolution through time of HIPEC have been addressed and covered. Special consideration had been given to the correlation between the carcinomatosis index and HIPEC. HIPEC with maximal cytoreduction can be considered a curative procedure only in strictly selected patients diagnosed with colorectal cancer and peritoneal carcinomatosis. Although it has been present in the medical field for almost 30 years, it is not wide-spread due to the high costs of implementation and the requirement of highly specialized surgical and medical teams. As technology evolves, the costs can be decreased and HIPEC should be largely available in oncological centers since the foundation of implementation is solid and the fact that clear benefits although small have been demonstrated. Taking into account all of the above, HIPEC should not be considered a standard treatment at present and should only be performed in experienced centers. The correct selection of patients is critical to the success of this procedure. Maximum cytoreduction should only be performed if the carcinomatosis index allows.



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