CURRENT MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL FEATURES OF MALE BREAST CANCER

A C Tutovan; G Drăghici; S M Oprescu

doi:10.33695/jss.v6i2.270

A C Tutovan 1Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
G Drăghici 2Clinical Nephrology Hospital ”Dr. Carol Davila”, Bucharest, Romania
S M Oprescu 1The University of Medicine and Pharmacy ”Carol Davila”, Bucharest, Romania 2Emergency University Hospital of Bucharest, Romania

DOI: https://doi.org/10.33695/jss.v6i2.270

Keywords: male breast cancer, invasive ductal carcinoma, ER receptor

Abstract

Breast cancer continues to be a leading cause of death among women aged over 40 years. This type of neoplasm is diagnosed quite rarely in male sex over 60 years, with an incidence almost 100 times lower in men versus women. No definite cause of occurrence of this ailment has been yet discovered in male sex, as well as in the case of breast cancer in female sex, but both environmental and genetic factors are incriminated. It appears that BRCA2 mutations are associated with increased risk of male breast cancer (MBC) and invasive ductal carcinoma is the predominant histological type of disease, which is positivity of both estrogen and progesterone receptors. This review was made with an aim to analyze morphological and immunohistochemical features on male breast cancer. PubMed and Medscape were used to identify systematic reviews published using the title term “molecular subtype of male breast cancer”.