COARCTATION OF THE AORTA IN A FETUS WITH 46, XY, INV (9)(P12,Q13) KARYOTYPE FOLLOWING IN VITRO FERTILIZATION

Liana Pleș1,2, Anca Ricu1, Romina-Marina Sima1,2, C.A. Ionescu2,3
1„St. John” Hospital, „Bucur” Maternity, Bucharest, Romania
2The University of Medicine and Pharmacy „Carol Davila”, Bucharest, Romania
3„St. Pantelimon” Hospital, Bucharest, Romania
Corresponding author: Romina-Marina Sima
Phone no. 0040741071243
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Abstract

The first pregnancy after the fertilization of a human egg in vitro and the first birth from an in vitro-fertilized embryo were reported in 1976 and 1978. Since then, more than five million pregnancies have been achieved worldwide by assisted reproductive technologies (ARTs). With ART improvement the questions about neonatal outcome and genetic implications are rising.The patient SM, 47 years of age, referred to our clinic for pregnancy prenatal care. Due to poor ovarian reserve related to her biological age she obtained this pregnancy using ART procedures. The second trimester anomaly ultrasound scan revealed coarctation of the aorta.The genetic examination of the amniotic fluid observed a male fetus with 46, XY,inv (9)(p12,q13) karyotype. The outcome of the pregnancy was favorable without hemodynamic changes in the fetus until birth. The patient delivered by cesarian section a 3200 g baby-boy with 9 Apgar Score. The cardiologic consult confirmed the mild coarctation of the aorta. The question that rises is: which is the cause, the IVF, the chromosome inversion or other environmental factors?

Keywords: aortic coarctation, in vitro fertilization, assisted reproductive technologies

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