Ana Valea1,2, V. Muntean1,2, Andra Morar2, Mara Carsote 4,5, Cristina Căpăţână4,5, Simona Elena Albu 4,6

1The University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca, Romania
2The Department of Endocrinology, The Clinical County Hospital, Cluj-Napoca, Romania
3The CFR Hospital, Cluj-Napoca, Romania
4The University of Medicine and Pharmacy “Carol Davila”, Bucharest, Romania
5The National Institute of Endocrinology “C. I. Parhon” Bucharesti, Romania
6The University Emergency Hospital, Bucharest, Romania

Corresponding author: Maria Carsote
Phone no. 0040213172041
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Recurrent primary hyperparathyroidism is characterized by typical symptoms and biochemical recurrence of hypercalcemia after more than 6 months of normal calcium levels after surgery. We report the case of a 39-year-old female patient presenting with menses disturbances who was diagnosed with primary hyperparathyroidism caused by a left inferior parathyroid adenoma at the age of 35. Postoperative 6-month follow-up showed normalization of biochemical and hormonal profiles, with significant improvement of clinical symptoms, dominated by muscle weakness, weight loss and oligomenorrhea. The 18-month follow-up showed elevated PTH and serum calcium levels. Imaging confirmed recurrence of primary hyperparathyroidism by highlighting a right upper parathyroid adenoma. Surgery was performed again and no major incident was seen. The particularity of this case consists in the recurrence of primary hyperparathyroidism in a young patient with no family history of the disease due to asynchronous parathyroid adenomas that were successfully removed in a female patient who in addition to classic complications such as calyceal microlithiasis and osteoporosis presented oligomenorrhea which was resolved spontaneously after the correction of hypercalcemia.


Keywords: parathyroidectomy, recurrent hyperparathyroidism, hypercalcemia, oligomenorrhea

Sunday the 18th.