GIANT RETROPERITONEAL LIPOSARCOMA WITH ENTERAL AND BLADDER COMPRESSION–CASE PRESENTATION AND LITERATURE REVIEW

D.C. Badiu1,2, Mihaela Mandu1, I.C. Bârsan2, C. Prală2, V. Porojan2, V. Mădan1,3, A. Aungurenci3, S. Bedereag 4, Romina Maria Sima1, V. T. Grigorean1,2
1The University of Medicine and Pharmacy “Carol Davila”, Bucharest, Romania
2Surgery Department of Clinical Emergency Hospital “Bagdasar-Arseni”, Bucharest, Romania
3Urology Department of University Emergency Central Military Hospital “Dr. Carol Davila”, Bucharest, Romania
4Pathology department of Clinical Emergency Hospital “Bagdasar-Arseni”, Bucharest, Romania
Corresponding author: Mihaela Mandu
Phone no. 0040737501712
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Abstract

Liposarcomas are the most common retroperitoneal sarcomas, occurring more frequently in the age range of 40-60 years. The purpose of this article is to highlight the diagnostic and therapeutic modalities of retroperitoneal giant liposarcomas exemplifying by presenting a 41 year old patient with a large retroperitoneal tumor (29/24/12 cm) excised with difficulty to healthy tissue and following the histopathological result, it was shown to be a primitive liposarcoma with variable profile. The patient had a good post-operative evolution and refused any adjuvant treatment (radiotherapy). He developed a large local relapse associated with vertebral metastases, with reintervention having a very difficult tumor reduction but with unfavorable postoperative evolution, with multiple organic dysfunction syndrome leading to the patient's death. Analyzing the data from the literature, we concluded that complete surgical excision with the affected organs and structures is the gold standard of treatment, but tumor recurrences are frequent (especially for dedifferentiated subtypes) and lead to increased mortality rates; adjuvant or neoadjuvant radiotherapy can help to prevent such relapses (there are still many ongoing clinical studies).

Keywords: tumor, retroperitoneal, giant, liposarcoma, excision

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