GASTRIC CARCINOMA BETWEEN HIGH GRADE NEUROENDOCRINE FEATURES AND ADENOCARCINOMA: A CASE REPORT AND BRIEF REVIEW OF LITERATURE

Denisa-Maria Zolofinoiu1, O. Andronic1, D. N. Păduraru1,2,Alexandra Bolocan1,2, T.A. Georgescu1,3
1The University of Medicine and Pharmacy “Carol Davila”, Bucharest, Romania
23rd Department of General Surgery, The University Emergency Hospital, Bucharest, Romania
3Department of Pathology, The University Emergency Clinical Hospital, Bucharest, Romania
Corresponding author: Octavian Andronic
Phone no. 0040724024019
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Abstract

Mixed adenoneuroendocrine carcinoma (MANEC) is an exceptionally rare type of cancer associated to the gastrointestinal tract, without a clearly established and optimal therapeutic management. These tumors present with non-specific symptoms or histopathological findings to distinguish them from pure adenocarcinomas. We report the case of a 64-year-old male diagnosed with a high grade mixed adeneuroendocrine carcinoma of the gastric antrum, stage T2N3Mx. The patient underwent radical gastrectomy and the histopathological examination of the surgically resected specimen revealed a tumor mass containing both adenocarcinoma and poorly differentiated neuroendocrine components. Immunostaining for Chromogranin A and Synaptophysin was positive in the neuroendocrine component and negative in the adenocarcinoma component, which was positive for CK7 and CK20. Ki67 proliferation index was 95%. Using this report as reference, we also discuss the imunohistopathological features, clinical behavior and therapeutic management of mixed adenoneuroendocrine carcinomas, presenting a brief review of literature regarding this rare, yet highly aggressive tumor.

Keywords: MANEC, gastrectomy, immunostaining

We have 30 guests and no members online

Friday the 20th.